Friday, September 23, 2016

Oxidation - maybe the ultimate agent in aging

Oxidation causes damage to cellular organelles, proteins, DNA nucleotids. However these all can be repaired by the cell, because there are templates.
There is one thing that's hard to repair - the methylation state of the DNA. Because the methylation state of the cell only resets early in embryogenesis and from then on its a one way process.
There are enzymes that can actively remove methyl group from cystein through oxidation.
Maybe the process works in an active manner too?

The Emerging Nexus of Active DNA Demethylation and Mitochondrial Oxidative Metabolism in Post-Mitotic Neurons

Mechanism and Function of Oxidative Reversal of DNA and RNA Methylation

Genome-wide Analysis Reveals
TET- and TDG-Dependent
5-Methylcytosine Oxidation Dynamics

Charting oxidized methylcytosines at base resolution

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