Saturday, June 11, 2016

Age related changes in bone caused by shift in stem cell differentiation?

First paper, expression profile, DNA methylation changes in mesenchynal osteo progenitor cells
Many differences between aged and young? Is there a casual relationship between methylation and expression? Couldnt find it out from the abstract.

Second paper claims that epigenetics (my favourite Polycomb repressor group2) influences the balance in differentiation into osteoblast or adipocyte, suggesting this is the reason for age related bone loss and age related obesity. However here PRC2 catalytic subunit EZH2 is upregulated by age - previously PRC2 targets got methylated by aging. This is controversial at first sight. Need to get the paper.

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